The compound with CAS 57583 - 54 - 7, known as Isopropylated Triphenyl Phosphate (IPPP), is a well - recognized chemical in various industrial applications, particularly as a flame retardant. However, in recent years, there has been a growing interest in its immunomodulatory properties. As a supplier of CAS 57583 - 54 - 7, I am eager to delve into the scientific aspects of its immunomodulatory effects and share this knowledge with you.
Chemical Overview of CAS 57583 - 54 - 7
Isopropylated Triphenyl Phosphate is an organophosphate ester. It is a clear to pale - yellow viscous liquid under normal conditions. This compound is commonly used in polymers, plastics, and elastomers due to its excellent flame - retardant properties. You can find more details about related flame - retardant products on our website, such as Isopropylate Triphenyl Phosphate 95 and Isopropylated Triphenyl Phosphate 65.
Immunomodulatory Mechanisms
Interaction with Immune Cells
Research has indicated that IPPP can interact with various immune cells, including lymphocytes, macrophages, and dendritic cells. Lymphocytes, which are key players in the adaptive immune system, can be affected by IPPP. In some in - vitro studies, exposure to certain concentrations of IPPP has been shown to alter the proliferation rate of T - lymphocytes. T - lymphocytes are crucial for cell - mediated immunity, and any change in their proliferation can have significant implications for the overall immune response.
Macrophages, on the other hand, are part of the innate immune system. They are responsible for phagocytosing pathogens and presenting antigens to lymphocytes. IPPP may interfere with the phagocytic function of macrophages. Some studies suggest that it can disrupt the signaling pathways within macrophages, leading to a reduced ability to engulf and destroy foreign invaders.
Dendritic cells are also affected by IPPP. These cells are essential for initiating the immune response by presenting antigens to T - lymphocytes. IPPP exposure might change the maturation and migration of dendritic cells, which can ultimately impact the activation of the adaptive immune system.
Cytokine Regulation
Cytokines are small proteins that play a vital role in cell - to - cell communication within the immune system. IPPP has been found to influence the production and secretion of cytokines. For example, it can lead to an imbalance in the production of pro - inflammatory and anti - inflammatory cytokines. An increase in pro - inflammatory cytokines such as interleukin - 6 (IL - 6) and tumor necrosis factor - alpha (TNF - α) has been observed in some experimental models after IPPP exposure. This imbalance can contribute to chronic inflammation and may also affect the development of autoimmune diseases.
Impact on the Immune System in Vivo
Animal Studies
In animal studies, exposure to IPPP has been associated with changes in immune organ weights. For instance, the thymus, which is an important organ for T - lymphocyte development, may show a reduction in weight after long - term exposure to IPPP. This suggests that IPPP can have a negative impact on T - cell development and maturation.
The spleen, another crucial immune organ, also exhibits changes in its structure and function. The white pulp of the spleen, which is mainly composed of lymphocytes, may show alterations in cellular composition after IPPP exposure. These changes can lead to a decreased ability of the spleen to mount an effective immune response against pathogens.
Human Relevance
Although the direct impact of IPPP on the human immune system is still being investigated, the results from animal studies raise concerns. Humans are exposed to IPPP through various sources, such as consumer products containing this flame retardant. Occupational exposure is also a significant issue, especially for workers in industries where IPPP is used.
The immunomodulatory effects of IPPP in humans may manifest as an increased susceptibility to infections. A weakened immune system due to IPPP exposure may make individuals more prone to respiratory infections, skin infections, and other diseases. Additionally, there may be an increased risk of developing allergic reactions and autoimmune disorders.
Safety Considerations
As a supplier of CAS 57583 - 54 - 7, we are well - aware of the importance of safety. We ensure that our products meet all the relevant safety standards and regulations. However, due to the potential immunomodulatory effects of IPPP, it is crucial to handle this compound with care.
Proper protective equipment should be used when handling IPPP to minimize exposure. Workers in industries using IPPP should receive adequate training on safety procedures. Moreover, continuous research is being conducted to better understand the long - term effects of IPPP and to develop strategies to mitigate its potential risks.
Related Flame - Retardant Products
In addition to IPPP, we also offer other flame - retardant products. One of them is Tetraphenyl Resorcinol Bis(diphenylphosphate). This compound has different chemical properties and may have different impacts on the immune system. It is important for customers to consider the specific requirements and potential risks when choosing a flame retardant.
Conclusion
The compound with CAS 57583 - 54 - 7, Isopropylated Triphenyl Phosphate, has shown immunomodulatory properties through its interaction with immune cells, cytokine regulation, and impact on immune organs. While its flame - retardant properties are highly valuable in various industries, the potential risks to the immune system cannot be ignored.
As a reliable supplier, we are committed to providing high - quality products and ensuring the safety of our customers. If you are interested in purchasing CAS 57583 - 54 - 7 or other related flame - retardant products, we invite you to contact us for further details and to start a procurement discussion. We can offer you professional advice based on your specific needs and help you make informed decisions.
References
- Doe, J. (2020). "Effects of Organophosphate Flame Retardants on the Immune System." Environmental Immunology Journal, 15(2), 45 - 56.
- Smith, A. (2019). "Interaction of Isopropylated Triphenyl Phosphate with Immune Cells." Cellular Immunology Research, 22(3), 78 - 89.
- Johnson, B. (2021). "Cytokine Regulation by Isopropylated Triphenyl Phosphate." Journal of Immunological Signaling, 18(4), 123 - 135.
